Premium
Size and Shape Effects of Near‐Infrared Light‐Activatable Cu 2 (OH)PO 4 Nanostructures on Phototherapeutic Destruction of Drug‐Resistant Hypoxia Tumors
Author(s) -
Nuthalapati Karthik,
Vankayala Raviraj,
Chiang ChiShiun,
Hwang Kuo Chu
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202000001
Subject(s) - singlet oxygen , nanomaterials , photodynamic therapy , photothermal therapy , reactive oxygen species , chemistry , biodistribution , in vivo , phototoxicity , drug delivery , photochemistry , radical , nanoparticle , nanotechnology , tumor hypoxia , biophysics , oxygen , therapeutic index , materials science , drug , in vitro , radiation therapy , pharmacology , medicine , biochemistry , organic chemistry , biology , microbiology and biotechnology
Development of simple, robust, and noninvasive therapeutic approaches to treat cancers and improve survival rates is a grand challenge in clinical biomedicine. In particular, the sizes and shape of the nanomaterials play a vital role in dictating their biodistribution and clearance pathways. It remains elusive how the size and shape of a nanomaterial affect its therapeutic efficacy in cancer diagnosis and treatments. To tackle the above problem, the effects of size and shape of Cu 2 (OH)PO 4 nanostructures (nanosheets and quantum dots) on the photodynamic therapy (PDT) in destroying malignant drug‐resistant lung tumors and on combating the tumor hypoxia problem are investigated and compared. The photocatalytic mechanism of Cu 2 (OH)PO 4 nanostructures mainly involves the generation of reactive oxygen species (ROS), such as hydroxyl radical ( · OH) and singlet oxygen ( 1 O 2 ). Under an oxygen deprivation condition, Cu 2 (OH)PO 4 nanosheets still can generate OH radicals to kill cancer cells upon near‐infrared (NIR) light irradiation. Overall, in vitro and in vivo experiments show that Cu 2 (OH)PO 4 nanosheets can overcome tumor hypoxia problems and effectively mediate dual modal PDT and photothermal therapeutic (PTT) effects on destruction of NCI‐H23 lung tumors in mice using ultralow doses (350 mW cm −2 ) of NIR (915 nm) light.