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Combinatorial Drug Therapy: Compartmentalized Encapsulation of Two Antibiotics in Porous Nanoparticles: an Efficient Strategy to Treat Intracellular Infections (Part. Part. Syst. Charact. 3/2019)
Author(s) -
Li Xue,
Semiramoth Nicolas,
Hall Shaun,
Tafani Virginie,
Josse Jérome,
Laurent Frederic,
Salzano Giuseppina,
Foulkes Daniel,
Brodin Priscille,
Majlessi Laleh,
Ghermani NourEddine,
Maurin Guillaume,
Couvreur Patrick,
Serre Christian,
BernetCamard MarieFrançoise,
Zhang Jiwen,
Gref Ruxandra
Publication year - 2019
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201970009
Subject(s) - intracellular , encapsulation (networking) , nanoparticle , drug , amoxicillin , antibiotics , bacteria , chemistry , nanotechnology , biophysics , materials science , pharmacology , medicine , biology , biochemistry , computer network , computer science , genetics
As demonstrated by Ruxendra Gref and co‐workers in article number 1800360 , two synergic drugs, amoxicillin and potassium clavulanate, were co‐encapsulated within highly porous nanoparticles made of metal‐organic frameworks (nanoMOFs). Within the interconnected 3D structure, each drug located in a separate compartment and these findings were supported by molecular simulations. NanoMOFs were efficiently internalized in infected macrophages and contributed together with the entrapped drugs to kill intracellular bacteria.