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Gold Nanoparticle Bioconjugates: Display of Potassium Channel–Blocking Tertiapin‐Q Peptides on Gold Nanoparticles Enhances Depolarization of Cellular Membrane Potential (Part. Part. Syst. Charact. 3/2019)
Author(s) -
Muroski Megan E.,
Oh Eunkeu,
Deschamps JeffreyR.,
Delehanty James B.
Publication year - 2019
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201970007
Subject(s) - depolarization , colloidal gold , chemistry , biophysics , nanoparticle , bioconjugation , potassium channel , membrane , peptide , membrane potential , conjugate , ion channel , nanotechnology , materials science , combinatorial chemistry , biochemistry , receptor , biology , mathematical analysis , mathematics
In article number 1800493 , James B. Delehanty and co‐workers demonstrate a gold nanoparticle (AuNP)‐peptide bioconjugate system for the augmented blockage of potassium channels and control over membrane potential in electrically active cells. The display of multiple peptides on the AuNP surface facilitates the enhanced depolarization of membrane potential compared to peptide alone. The effects of this NP conjugate system are photothermally reversible, providing a new research tool for modulating ion channel activity and cellular membrane potential.