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Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging
Author(s) -
Vidallon Mark Louis P.,
Douek Alon M.,
Quek Adam,
McLiesh Heather,
Kaslin Jan,
Tabor Rico F.,
Bishop Alexis I.,
Teo Boon Mian
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201900471
Subject(s) - nanomaterials , coating , nanoparticle , bovine serum albumin , calcium carbonate , materials science , nanotechnology , membrane , chemical engineering , photothermal therapy , chemistry , chromatography , organic chemistry , biochemistry , engineering
This work reports the fabrication of biocompatible and pH‐sensitive hybrid polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO 3 ) particles via a rapid precipitation method. These hybrid particles generate hyperechogenic carbon dioxide bubbles upon exposure to low pH environments, making them ideal as a contrast agent and detector for tumor cells. This study also highlights the application of red blood cell membrane (RBC)‐derived membranes as a biomimetic coating for PDA/BSA/CaCO 3 hybrid particles in order to modulate protein corona formation, a natural physiological response that alters tailored properties of most nanomaterials that are administered systemically. Results of this work demonstrate that the RBC membrane‐coated hybrid particles are ideal for a wide range of biomedical applications, such as noninvasive multimodal imaging, photothermal and photodynamic therapy, and “personalized” drug delivery systems.