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Metal–Drug–Protein Assemblies: Gd 3+ Self‐Enhanced Magnetic Resonance Imaging, High‐Sensitive Tumor‐Targeting Imaging and Efficient Chemo‐Phototherapy
Author(s) -
Zhou Jia,
Li Tianliang,
Zhang Yiran,
Xu Xiaoyu,
Zhang Chunlei,
Li Yuehua,
Cui Daxiang,
Cheng Yingsheng
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201900427
Subject(s) - magnetic resonance imaging , in vivo , photothermal therapy , gadolinium , nuclear magnetic resonance , in vitro , mri contrast agent , chemistry , materials science , chelation , cancer research , biophysics , medicine , nanotechnology , radiology , biochemistry , physics , microbiology and biotechnology , organic chemistry , biology
Magnetic resonance imaging (MRI) contrast agents are broadly employed for better clinical trials in MR imaging. Magnevist solution (Gd‐DTPA), a clinical MRI contrast agent, possesses inherent shortcomings like poor r 1 relaxation, short half‐time, nephrotoxicity, etc. To overcome these problems, Gd‐DTPA‐grafted protein assemblies (Gd‐P‐ABs) loading with anticancer drug cisplatin and photosentizer IR‐780 are constructed via chelation of Gd 3+ . Gd‐P‐ABs exhibit dual MR/fluorescence (FL) imaging–guided chemo/photothermal therapy. Interestingly, Gd‐P‐ABs behave as aggregation‐enhanced magnetic resonance imaging with an extremely high r 1 value of 26.391 s −1 m m −1 , which is about 5.5‐fold larger than Gd‐DTPA (≈4.8 s −1 m m −1 ). Consequently, better MRI performance is presented with the same concentration of Gd ions. When exposed to acidic tumor microenvironment and light irradiation, Gd‐P‐ABs show significant drug release capacity. Good cell killing ability in vitro is also determined due to effective folate‐targeting ability and high photo–heat conversion. In vivo MR/FL imaging results reveal that Gd‐P‐ABs possess high‐sensitivity tumor‐targeting imaging and long tumor retention, which are attributed to the folate‐targeting ability and small size effect. Combined chemo/photothermal therapy in vivo demonstrates that the tumor can be eventually ablated. Altogether, the Gd‐P‐ABs possess great potential for clinical imaging‐guided tumor therapy.