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Construction of a Dual Drug Carrier on the Basis of Hollow Structured Upconversion Nanoparticles for pH‐Responsive Drug Delivery and UCL/MRI Dual Mode Imaging
Author(s) -
Liu Yana,
Feng Yiming,
Xu Chen,
He Hailu,
Zhang Yongqi,
Xu Zushun,
Li Ling,
Wang Jing
Publication year - 2019
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201900200
Subject(s) - doxorubicin hydrochloride , dual mode , drug delivery , imaging agent , chemistry , magnetic resonance imaging , nanoparticle , methotrexate , in vivo , biomedical engineering , materials science , doxorubicin , nuclear chemistry , nanotechnology , medicine , chemotherapy , radiology , surgery , microbiology and biotechnology , engineering , biology , aerospace engineering
A series of Gd 3+ doping hollow upconversion nanoparticles NaYF 4 :Yb,Gd,Tm (h‐UNCP) are prepared successfully. The hollow NaYF 4 :Yb,Gd,Tm possess excellent upconversion luminescence (UCL) and large longitudinal relativity ( r 1 = 128.3 m m −1 s −1 ), which can be potentially used for UCL/magnetic resonance imaging (MRI) dual mode imaging. On the basis of the optimal h‐UCNP, doxorubicin hydrochloride (DOX) and methotrexate (MTX) are used as drug models to prepare a dual drug carrier. After the encapsulation of DOX on the h‐UCNP, chitosan (CS) is further wrapped and then used to load MTX to obtain a dual drug carrier h‐UCNPs/DOX/CS/MTX. The pH responsive release of DOX and MTX is discussed. The MTX release climbs from 33% to 100% by regulating the pH from 5.8 to 7.4. The DOX release is different at different pH conditions. The synergistic effect of DOX and MTX on the cancer cells is confirmed by cell viability. The h‐UCNPs/DOX/CS/MTX are tracked by cells UCL imaging and vivo MRI imaging. The excellent performance of UCL imaging and positive MRI images demonstrates that h‐UCNPs/DOX/CS/MTX can be used for UCL/MRI dual mode imaging. All the results show the potential application of h‐UCNPs/DOX/CS/MTX in pH responsive release and UCL/MRI dual imaging.