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Protein Corona Modulates Distribution and Toxicological Effects of Silver Nanoparticles In Vivo
Author(s) -
Barbir Rinea,
Goessler Walter,
Ćurlin Marija,
Micek Vedran,
Milić Mirta,
Vuković Barbara,
Milić Marija,
Ljubojević Marija,
Domazet Jurašin Darija,
Vinković Vrček Ivana
Publication year - 2019
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201900174
Subject(s) - in vivo , silver nanoparticle , chemistry , nanotoxicology , nanomedicine , genotoxicity , biophysics , biomedicine , oxidative stress , nanotechnology , microbiology and biotechnology , nanoparticle , biochemistry , toxicity , biology , materials science , bioinformatics , organic chemistry
Abstract Exploitation of silver nanoparticles (AgNPs) in biomedicine represents more than one third of their overall applications. Despite their wide use, detailed toxicokinetic data and information on their action mechanisms in vivo are still scarce. One important obstacle is their fate and transformation patterns in biological environments where AgNPs get a “new face” after interaction with biomolecules, particularly proteins. The impact of protein corona on AgNP effects in vivo is eludicated. The in vivo effects of AgNPs prepared with two different protein coronas, albumin, and metallothionein, with polymer‐coated AgNPs are compared in male and female Wistar rats after intravenous administration. The results demonstrate that the character of the protein coronas on the AgNP surface affects not only distribution, but also oxidative stress response and genotoxicity in tissues of rat exposed to AgNPs. Additionally, sex‐related effects are observed. By emphasizing the importance of protein corona formation and sex‐related response, the obtained data support a reliable evidence base needed for assessing the health risks of the steadily increasing human exposure to AgNPs.