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Biodegradable Ultrasmall‐in‐Nano Gold Architectures: Mid‐Period In Vivo Distribution and Excretion Assessment
Author(s) -
Cassano Domenico,
Summa Maria,
PocovíMartínez Salvador,
Mapanao AnaKatrina,
Catelani Tiziano,
Bertorelli Rosalia,
Voliani Valerio
Publication year - 2019
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201800464
Subject(s) - biocompatibility , in vivo , nanotechnology , noble metal , nephrotoxicity , nanomedicine , colloidal gold , materials science , chemistry , nanoparticle , metal , medicine , kidney , biology , microbiology and biotechnology , metallurgy
Abstract The persistence of metals in the body after the designed theranostic action has hampered the clinical translation of noble metal nanoparticles (NPs) to clinics. Therefore, the appealing behaviors of NPs for healthcare applications are still on the bench‐side. Here, quantitative evaluation in healthy murine models show that gold comprised in passion fruit‐like nanoarchitectures (NAs) are excreted daily over a 10 d period by both renal and biliary pathways after biodegradation to the building blocks. Furthermore, histological analyses confirm the absence of nephrotoxicity and the remarkable biocompatibility of NAs up to the higher tested amount of 150 mg kg −1 . These in vivo findings demonstrate that NAs are the first full‐inorganic disassembling nanoplatforms exhibiting a noticeable excretion rate from model organisms. Such results are a significant step in bringing noble metal nanotheranostics to the forefront of cancer treatments once again.