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Spatially Controlled Molecular Encapsulation in Natural Pine Pollen Microcapsules
Author(s) -
Prabhakar Arun Kumar,
Potroz Michael G.,
Park Soohyun,
Miyako Eijiro,
Cho NamJoon
Publication year - 2018
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201800151
Subject(s) - encapsulation (networking) , pinus massoniana , pollen , drug delivery , nanotechnology , materials science , computer science , botany , biology , computer network
The loading of multiple drugs into a single carrier is an effective advanced clinical therapeutic for various diseases. Here, by exploiting the architectural features of natural pine pollen from Pinus massoniana , the spatially controlled encapsulation of two types of molecules in distinct compartments of a single microparticulate carrier is demonstrated. By simple vacuum and passive loading, diverse molecules such as proteins, organic dyes, and a drug are effectively encapsulated into the pollen microcapsule in binary fashion. This technique represents an advancement toward the use of natural pollen grains as a multifunctional molecular vehicle for functional drug delivery systems and innovative theranostic microdevices.