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HoF 3 and DyF 3 Nanoparticles as Contrast Agents for High‐Field Magnetic Resonance Imaging
Author(s) -
GonzálezMancebo Daniel,
Becerro Ana I.,
Rojas T. Cristina,
GarcíaMartín Maria L.,
de la Fuente Jesús M.,
Ocaña Manuel
Publication year - 2017
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201700116
Subject(s) - rhombus , holmium , nanoparticle , ethylene glycol , materials science , homogeneous , nanotechnology , precipitation , nuclear magnetic resonance , magnetic resonance imaging , chemistry , optics , physics , organic chemistry , radiology , medicine , laser , geometry , mathematics , meteorology , thermodynamics
Clinical contrast agents (CAs) currently used in magnetic resonance imaging (MRI) at low fields are less effective at high magnetic fields. The development of new CAs is mandatory to improve diagnostic capabilities of the new generation of high field MRI scanners. The purpose of this study is to synthesize uniform, water dispersible LnF 3 (Ln = Ho, Dy) nanoparticles (NPs) and to evaluate their relaxivity at high magnetic field (9.4 T) as a function of size and composition. Two different types of HoF 3 NPs are obtained by homogeneous precipitation in ethylene glycol at 120 °C. The use of holmium acetate as holmium precursor leads to rhombus‐like nanoparticles, while smaller, ellipsoid‐like nanoparticles are obtained when nitrate is used as the holmium salt. To explain this behavior, the mechanism of formation of both kinds of particles is analyzed in detail. Likewise, rhombus‐like DyF 3 nanoparticles are prepared following the same method as for the rhombus‐like HoF 3 nanoparticles. We have found, to the best of knowledge, the highest transverse relaxivity values at 9.4 T described in the literature for this kind of CAs. Finally, the LnF 3 NPs have shown negligible cytotoxicity for C6 rat glioma cells for concentrations up to 0.1 mg mL −1 .