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The Inhibition Effect of Graphene Oxide Nanosheets on the Development of Streptococcus mutans Biofilms
Author(s) -
He Jianliang,
Zhu Xiaodan,
Qi Zhengnan,
Wang Lihua,
Aldalbahi Ali,
Shi Jiye,
Song Shiping,
Fan Chunhai,
Lv Min,
Tang Zisheng
Publication year - 2017
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201700001
Subject(s) - biofilm , streptococcus mutans , graphene , microbiology and biotechnology , oxide , chemistry , nanotechnology , bacteria , materials science , biology , genetics , organic chemistry
Bacterial biofilms play a critical role in dental pathogenic mechanisms due to their ability to tolerate many traditional antibacterial agents. Thus, it is crucial to find effective methods to inhibit the occurrence and development of biofilms. Recently, graphene oxide (GO) nanosheets have become a promising antibacterial nanomaterial for use in various applications. This study focuses on the effect of GO nanosheets on the development of Streptococcus mutans biofilms. It is found that GO nanosheets are highly effective at inhibiting the formation of bacterial biofilms at concentrations ranging from low to high in early development stages. After GO treatment, the ratio of living cells in the biofilm decreases significantly, and the biofilm structure is destroyed. In contrast, GO has a minimal effect on mature biofilms.