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Templated Phospholipid Bilayers: Mosaic Interdigitated Structure in Nanoparticle‐Templated Phospholipid Bilayer Supports Partial Lipidation of Apolipoprotein A‐I (Part. Part. Syst. Charact. 6/2016)
Author(s) -
Sun Wangqiang,
Wu Weiqiang,
McMahon Kaylin M.,
Rink Jonathan S.,
Thaxton C. Shad
Publication year - 2016
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201670017
Subject(s) - lipid anchored protein , phospholipid , bilayer , lipid bilayer , nanoparticle , biophysics , amphiphile , chemistry , materials science , nanotechnology , membrane , biochemistry , organic chemistry , polymer , biology , copolymer , autophagy , apoptosis
Using gold‐nanoparticle‐templated high‐density lipoprotein‐like particles as a model, the nanoparticle‐templated phospholipid bilayer is studied from the bottom‐up in a work presented by W. Sun, C. S. Thaxton and co‐workers on page 300. Data support that the phospholipids have a mosaic interdigitated structure. The discontinuous lipid milieu supports partial lipidation of apolipoprotein A‐I, different from an ordinary phospholipid bilayer, suggesting that synergy between nanoparticle templates and bound phospholipid layers can modulate amphiphilic proteins for desired functions.