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Mesoporous Silica Promoted Deposition of Bioinspired Polydopamine onto Contrast Agent: A Universal Strategy to Achieve Both Biocompatibility and Multiple Scale Molecular Imaging
Author(s) -
Chen YuWei,
Peng YungKang,
Chou ShangWei,
Tseng YuJui,
Wu PeiChun,
Wang ShinKung,
Lee YiWei,
Shyue JingJong,
Hsiao JongKai,
Liu TzuMing,
Chou PiTai
Publication year - 2017
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201600415
Subject(s) - materials science , mesoporous silica , photothermal therapy , polyethylene glycol , nanotechnology , in vivo , mesoporous material , nanoparticle , biocompatibility , nanocomposite , coating , chemical engineering , biomedical engineering , chemistry , organic chemistry , catalysis , medicine , microbiology and biotechnology , engineering , biology , metallurgy
Polydopamine (PDA) preserves universal coating and metal‐binding ability, and is suitable for application in synthesizing multifunctional agents. Herein, utilizing mesoporous silica assisted deposition to enhance both heterogeneous nucleation and loading amounts of PDA, the magnetic resonance (MR) T 1 component (PDA‐Fe 3+ ) and MR T 2 /computed tomography (CT)/multiphoton luminescence (MPL) component (FePt) have been successfully integrated in aqueous solution. This four‐in‐one (T 1 , T 2 , CT, MPL) imaging nanocomposite, FePt@mSiO 2 @PDA‐polyethylene glycol (PEG), demonstrated its multi‐imaging power both in vitro/in vivo. According to our in vitro/in vivo results, FePt@mSiO 2 @PDA‐PEG reveals water‐content‐dependent property in T 1 MR imaging, which suggests the necessity of having dual‐modal MR ability in a single particle for the precision diagnosis. Most importantly, this dual (T 1 ,T 2 )‐MRI/CT contrast agent is demonstrated complementary to each other in the in vivo testing. PDA coated mesoporous silica also offers an advantage of delayed degradation that prevents adverse effects caused by silica fragments before excretion. The potential of this nanocomposites in both drug carrier and photothermal agent was further evaluated by using doxorubicin and monitoring solution temperature after irradiating 808 nm continuous‐wave, respectively The merits of controlled polymerization, enhanced PDA loading, and biofavorable degradation make this methodology promising to other nanoparticle@mSiO 2 for a wide range of bioapplications.