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Targeting Upconversion Nanoprobes for Magnetic Resonance Imaging of Early Colon Cancer
Author(s) -
Jin Yingying,
Ni Dalong,
Zhang Jiawen,
Han Fang,
Wang Jing,
Gao Lu,
Zhang Hua,
Liu Yanyan,
Cui Zhaowen,
Yao Zhenwei,
Feng Xiaoyuan,
Bu Wenbo
Publication year - 2017
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201600393
Subject(s) - magnetic resonance imaging , carcinoembryonic antigen , colorectal cancer , medicine , biocompatibility , materials science , cancer , nanotechnology , radiology , metallurgy
Colon cancer (CC) is one of the most common intestinal malignancies and is difficult to detect in its early stage by magnetic resonance imaging (MRI) with currently used contrast agents (CAs). The development of targeted CAs contributes to the early diagnosis of CC and thereby enables early intervention and timely therapy. Considering the outstanding performance of upconversion nanoprobes (UCNPs) in high‐performance MR and fluorescence imaging, a new type of nanoprobes with considerably enhanced imaging performance is developed herein. Carcinoembryonic antigen (CEA) antibody is conjugated onto the surface of UCNPs to achieve the targeted imaging of early CC tumors, which overexpress CEA. Both toxicity tests and histological/hematological examinations demonstrate the excellent biocompatibility of these CC‐targeting nanoprobes, which possess great potential for clinical application in the early diagnosis of CC.