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Tumor Microenvironment Responsive ACPP‐Conjugated Micelles for Targeted Treatment of Brain Glioma
Author(s) -
Zhu Xiaoyan,
Pang Zhiqing,
Shen Shun
Publication year - 2017
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201600201
Subject(s) - glioma , micelle , plasminogen activator , conjugated system , polyethylene glycol , drug delivery , chemistry , cancer research , computer science , biochemistry , medicine , organic chemistry , aqueous solution , polymer
A multitargeting drug delivery system based on micelles modified with urokinase‐type plasminogen activator‐sensitive activated cell‐penetrating peptides (uPA‐ACPP) for the treatment of brain glioma is first developed. Compared with the conventional polyethylene glycol‐poly(lactic acid) nanoparticles, smaller size, higher drug loading of micelles are more suitable for brain tumor treatment under the action of uPA‐sensitive ACPP.