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Magnetic Liposomal Particles for Magnetic Imaging, Sensing, and the pH‐Sensitive Delivery of Therapeutics
Author(s) -
Kwon YongSu,
Jang Su Jin,
Yoon Young Il,
Cho HeeSang,
Lee Hak Jong,
Cho YoungSeok,
Shin Hyun Soo,
Yoon TaeJong
Publication year - 2016
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201600041
Subject(s) - liposome , drug delivery , conjugated system , nanotechnology , computer science , in vitro , computational biology , chemistry , materials science , biology , biochemistry , physics , nuclear magnetic resonance , polymer
To maintain magnetic properties, physical properties, and bio‐applicability, a liposomal structure is introduced to the magnetic MNP@ m SiO 2 (MagLipo). EGFR‐antibody‐conjugated MagLipo is successfully applied for T 2 ‐ w imaging and magnetic sensing after specific targeting to BxPC3 pancreatic cancer. Furthermore, the MagLipo carrying a therapeutic drug and gene shows a high therapeutic effect with drug release in a pH‐sensitive manner in vitro.