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Theranostics: Polymer Capsules as a Theranostic Tool for a Universal In Vitro Screening Assay—The Case of Lysosomal Storage Diseases (Part. Part. Syst. Charact. 11/2015)
Author(s) -
Nazarenus Moritz,
Abasolo Ibane,
GarcíaAranda Natalia,
Voccoli Vladimir,
Rejman Joanna,
Cecchini Marco,
Schwartz Simó,
Rivera_Gil Pilar,
Parak Wolfgang J.
Publication year - 2015
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201570037
Subject(s) - endocytosis , in vitro , enzyme , organelle , chemistry , polymer , lysosomal storage disorders , fluorescence , biochemistry , nanotechnology , biophysics , microbiology and biotechnology , biology , materials science , cell , organic chemistry , physics , quantum mechanics
Polymer multilayer capsules are used by P. Rivera_Gil, W. J. Parak, and co‐workers for concomitant pH‐sensing and enzyme delivery to lysosomes in the framework of enzyme‐replacement therapy in lysosomal‐storage disorders, as described on page 991. The capsules act as local reporters of the pH by changing the fluorescence of the carried sensor from red (alkaline) to yellow (acidic) upon endocytosis and organelle acidification. In the acidic lysosomes, the capsules deliver the enzyme to substitute the defective one.