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Hydrophilic Cu 3 BiS 3 Nanoparticles for Computed Tomography Imaging and Photothermal Therapy
Author(s) -
Yang Yan,
Wu Huixia,
Shi Benzhao,
Guo Linlin,
Zhang Yingjian,
An Xiao,
Zhang Hao,
Yang Shiping
Publication year - 2015
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201400238
Subject(s) - polyvinylpyrrolidone , photothermal therapy , in vivo , nanoparticle , materials science , aqueous solution , solvent , irradiation , coating , nuclear chemistry , preclinical imaging , thermal decomposition , nanotechnology , chemistry , polymer chemistry , organic chemistry , physics , microbiology and biotechnology , nuclear physics , biology
Hydrophilic Cu 3 BiS 3 nanoparticles (NPs) have been prepared using the thermal decomposition of precursor complexes in oily‐mixed solvent followed by coating the produced Cu 3 BiS 3 NPs with polyvinylpyrrolidone (PVP). The resulting Cu 3 BiS 3 /PVP NPs remain stable in aqueous solutions over a long period of time, and meanwhile, they show low in vitro cytotoxicity and negligible toxicity to mice in vivo. Cu 3 BiS 3 /PVP NPs could operate as an efficient dual‐modal contrast agent to simultaneously enhance X‐ray computed tomography imaging and photothermal imaging of tumor model in vivo. Moreover, highly efficient ablation of cancer cells both in vitro and in vivo has been successfully achieved by combining Cu 3 BiS 3 /PVP NPs with near‐infrared (NIR) laser irradiation. All of the positive results in this study highlight that Cu 3 BiS 3 /PVP NPs could serve as a promising platform for cancer diagnosis and therapy.