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Red‐Emissive Chemiluminescent Nanoparticles with Aggregation‐Induced Emission Characteristics for In Vivo Hydrogen Peroxide Imaging
Author(s) -
Geng Junlong,
Li Kai,
Qin Wei,
Tang Ben Zhong,
Liu Bin
Publication year - 2014
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201400156
Subject(s) - chemiluminescence , hydrogen peroxide , in vivo , aggregation induced emission , nanoparticle , chemistry , photochemistry , in vitro , molecule , biophysics , reactive oxygen species , materials science , nanotechnology , fluorescence , chromatography , biochemistry , organic chemistry , optics , physics , microbiology and biotechnology , biology
Sensitive and selective H 2 O 2 detection: Chemiluminescent nanoparticles are fabricated utilizing fluorogens with aggregation‐induced emission characteristics and a H 2 O 2 ‐responsive molecule. The obtained nanoparticles not only exhibit good response to H 2 O 2 in vitro but also show high chemiluminescence in vivo using an LPS‐induced inflammation model.