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Advances in Anticancer Protein Delivery using Micro‐/Nanoparticles
Author(s) -
Sun Wujin,
Lu Yue,
Gu Zhen
Publication year - 2014
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201400140
Subject(s) - apoptosis , immune system , dna , cancer cell , nanotechnology , nanoparticle , chemistry , cancer , cancer research , microbiology and biotechnology , biology , materials science , biochemistry , immunology , genetics
Proteins exhibiting anticancer activities, especially those capable of discriminately killing cancer cells, have attracted increasing interest in developing protein‐based anticancer therapeutics. This Progress Report surveys recent advances in delivering anticancer proteins directly to tumor tissue for inducing apoptosis/necrosis or indirectly to antigen presenting cells for provoking immune responses. Protein delivery carriers such as inorganic particles, lipid particles, polymeric particles, DNA/protein‐based biomacromolecular particles, as well as cell based carriers are reviewed with comments on their advantages and limitations. Future challenges and opportunities are also discussed.