A Multifunctional Magnetic Composite Material as a Drug Delivery System and a Magnetic Resonance Contrast Agent | Zendy

Zhang Guilong | Zendy; Gao Junlan | Zendy; Qian Junchao | Zendy; Cai Dongqing | Zendy; Zheng Kang | Zendy; Yu Zhiwu | Zendy; Wang Junfeng | Zendy; Zhong Kai | Zendy; Zhang Xin | Zendy; Wu Zhengyan | Zendy

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A Multifunctional Magnetic Composite Material as a Drug Delivery System and a Magnetic Resonance Contrast Agent

Author(s) -

Zhang Guilong,

Gao Junlan,

Qian Junchao,

Cai Dongqing,

Zheng Kang,

Yu Zhiwu,

Wang Junfeng,

Zhong Kai,

Zhang Xin,

Wu Zhengyan

Publication year - 2014

Publication title -

particle and particle systems characterization

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.877

H-Index - 56

eISSN - 1521-4117

pISSN - 0934-0866

DOI - 10.1002/ppsc.201300366

Subject(s) - drug delivery , magnetic resonance imaging , biocompatibility , nanomedicine , mri contrast agent , nuclear magnetic resonance , materials science , nuclear chemistry , nanotechnology , iron oxide , composite number , chemistry , nanoparticle , composite material , metallurgy , radiology , medicine , physics

Magnetic iron oxide coated in hydrogenation silica (Fe 3 O 4 @HSiO 2 ) is constructed as both a tumor drug carrier and a magnetic resonance (MR) contrast agent. Colchicine (COLC) is loaded in Fe 3 O 4 @HSiO 2 with the highest amount of 28.3 wt% at pH 9. The release performance of COLC can be controlled by pH, as the porous HSiO 2 shell can partially shed at pH below 3.0 to facilitate the release of COLC. MR imaging (MRI) tests prove that Fe 3 O 4 @HSiO 2 at pH 3.0 (H + ‐Fe 3 O 4 @HSiO 2 ) shows a stronger MR contrast enhancement than Fe 3 O 4 . Cytotoxicity experiment indicates that Fe 3 O 4 @HSiO 2 has excellent biocompatibility and magnetic targeting performance. Additionally, COLC‐loaded Fe 3 O 4 @HSiO 2 (Fe 3 O 4 @HSiO 2 –COLC) displays a higher inhibition effect on tumor cells under a magnetic field than free COLC. The visibility upon MRI, high targeting, and pH‐controlled release characteristics of Fe 3 O 4 @HSiO 2 –COLC are favorable to achieve the aim of reducing side effects to normal tissues, making Fe 3 O 4 @HSiO 2 –COLC an attractive drug delivery system for nanomedicine.

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