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A Multifunctional Magnetic Composite Material as a Drug Delivery System and a Magnetic Resonance Contrast Agent
Author(s) -
Zhang Guilong,
Gao Junlan,
Qian Junchao,
Cai Dongqing,
Zheng Kang,
Yu Zhiwu,
Wang Junfeng,
Zhong Kai,
Zhang Xin,
Wu Zhengyan
Publication year - 2014
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201300366
Subject(s) - drug delivery , magnetic resonance imaging , biocompatibility , nanomedicine , mri contrast agent , nuclear magnetic resonance , materials science , nuclear chemistry , nanotechnology , iron oxide , composite number , chemistry , nanoparticle , composite material , metallurgy , radiology , medicine , physics
Magnetic iron oxide coated in hydrogenation silica (Fe 3 O 4 @HSiO 2 ) is constructed as both a tumor drug carrier and a magnetic resonance (MR) contrast agent. Colchicine (COLC) is loaded in Fe 3 O 4 @HSiO 2 with the highest amount of 28.3 wt% at pH 9. The release performance of COLC can be controlled by pH, as the porous HSiO 2 shell can partially shed at pH below 3.0 to facilitate the release of COLC. MR imaging (MRI) tests prove that Fe 3 O 4 @HSiO 2 at pH 3.0 (H + ‐Fe 3 O 4 @HSiO 2 ) shows a stronger MR contrast enhancement than Fe 3 O 4 . Cytotoxicity experiment indicates that Fe 3 O 4 @HSiO 2 has excellent biocompatibility and magnetic targeting performance. Additionally, COLC‐loaded Fe 3 O 4 @HSiO 2 (Fe 3 O 4 @HSiO 2 –COLC) displays a higher inhibition effect on tumor cells under a magnetic field than free COLC. The visibility upon MRI, high targeting, and pH‐controlled release characteristics of Fe 3 O 4 @HSiO 2 –COLC are favorable to achieve the aim of reducing side effects to normal tissues, making Fe 3 O 4 @HSiO 2 –COLC an attractive drug delivery system for nanomedicine.