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Theranostic Nanoplatforms for MRSA Detection and Destruction from Whole Blood
Author(s) -
Fan Zhen,
Khan Sadia Afrin,
Dai Xuemei,
Tchouwou Christine,
Lu Yuefeng,
Ray Paresh Chandra
Publication year - 2014
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201300169
Subject(s) - photothermal therapy , photodynamic therapy , staphylococcus aureus , blood stream , nanotechnology , medicine , whole blood , biomedical engineering , bacteria , materials science , chemistry , surgery , biology , organic chemistry , genetics
Bloodstream infection with methicillin‐resistant Staphylococcus aureus (MRSA) and other drug‐resistant bacteria kill several million people in the world every year. Detection of drug‐resistant bacteria in the blood stream is clinically important to save lives. Driven by this need, multifunctional theranostic nanoplatforms have been developed for simultaneous targeted imaging and multimodal photodestruction of MRSA in a whole‐blood sample. Experimental data for the whole‐blood sample spiked with MRSA show that the theranostic nanoplatform can be used for fluorescence imaging after magnetic separation even in a 10 −5 :1 ratio. A targeted photodynamic and photothermal combined treatment shows that the multimodal treatment regime can dramatically enhance the possibility of destroying MRSA in vitro. Therefore, our developed theranostic nanoplatform have a great potential as a fluorescent marker and as a light absorber for combined therapy in clinical settings. The possible mechanisms and operating principles are discussed for targeted imaging and combined therapeutic actions using theranostic nanoplatform.