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Fabrication of pH‐Tunable Calcium Phosphate Nanocapsules via Dendrimer‐Templated Assembly for Intracellular Lysosomal Release of Drugs
Author(s) -
Khandare Jayant J.,
JalotaBadhwar Archana,
Taneja Neetika,
Mascarenhas Russel R.,
Vadodaria Karan,
Zope Khushbu R.,
Banerjee Shashwat S.
Publication year - 2013
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.201300034
Subject(s) - nanocapsules , dendrimer , nanotechnology , chemistry , drug delivery , polymer , dissolution , materials science , polymer chemistry , organic chemistry , nanoparticle
A pH‐responsive dendrimer templated polymer‐calcium phosphate core shell nanostructure is developed. Upon exposure to cellular lysosomal pH, a guest anticancer drug is released from the nanocapsule by dissolution of the CaP shell. Such a stimuli responsive carrier enables on‐demand controlled release of drugs in acidic organelles.