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Characterization of Particle Swelling of Materials of Pharmaceutical Interest
Author(s) -
Caramella Carla,
Ferrari Franca,
Bonferoni M. Cristina
Publication year - 1990
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.19900070125
Subject(s) - swelling , coulter counter , particle (ecology) , materials science , volume (thermodynamics) , characterization (materials science) , particle size , repeatability , inert , polystyrene , composite material , chemical engineering , nanotechnology , chromatography , chemistry , polymer , organic chemistry , oceanography , physics , microbiology and biotechnology , quantum mechanics , engineering , biology , geology
A method based on the employment of an electrical sensing zone instrument (Coulter Counter) has recently been proposed for the combined measurement of the increase in particle volume (particle swelling) and granulometric characterization of pharmaceutical tablet disintegrants. The performance of the method, as far as its applicability to limited swelling materials is concerned, has been assessed. Both inert materials (polystyrene latices) and limited swelling disintegrants (maize starch and crospovidone in different granulometric fractions) were examined for total particulate volume in aqueous media. The accuracy and repeatability of measurements of both total particulate volume and particle volume increase were defined. The results obtained indicate that the method may be adapted for measuring the increase in particle volume of so‐called limited swelling disintegrants.