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Study of the anticancer effects of a helium plasma jet combined with four anticancer drugs on 3D bladder tumour spheroids
Author(s) -
Zhang Jishen,
Li Bing,
Xu Shengduo,
Liu Dingxin,
Zhang Hao,
Xu Dehui,
Guo Li,
Kong Michael G.
Publication year - 2021
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.202000226
Subject(s) - atmospheric pressure plasma , jet (fluid) , plasma medicine , cisplatin , paclitaxel , plasma , bladder cancer , chemistry , pharmacology , medicine , cancer , chemotherapy , physics , quantum mechanics , thermodynamics
Current studies of cold atmospheric plasma cancer therapy mainly focus on the application of plasma alone and neglect the application of plasma combined with traditional therapeutic techniques. In this paper, the anticancer effects of a plasma jet combined with four clinical anticancer drugs (cisplatin, methotrexate, adriamycin and paclitaxel) on three‐dimensional bladder tumour spheroids (T24 cells) were studied. The results show that all four drugs had little impact on the liquid‐phase oxidative pressure induced by the plasma jet, and anticancer effects from strong to weak were as follows: Plasma jet + paclitaxel, plasma jet + adriamycin, plasma jet + cisplatin, plasma jet and plasma jet + methotrexate. Our research indicates that plasma exhibits selectivity in combination with particular anticancer drugs.