Premium
Application of plasma jet to the inhibition of the proliferation of hepatic malignant cells via reactive oxygen species generation
Author(s) -
Nguyen Duc Ba,
Mok Young Sun,
Huynh Do Luoung,
Jeong Dong Kee,
Lee Wong Gyu
Publication year - 2019
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201800173
Subject(s) - plasma , jet (fluid) , materials science , dielectric barrier discharge , reactive oxygen species , oxygen , chemistry , biophysics , analytical chemistry (journal) , dielectric , optoelectronics , chromatography , biochemistry , biology , organic chemistry , physics , quantum mechanics , thermodynamics
In vitro treatment of hepatic malignant cells with plasma‐activated medium conjugated with gemcitabine was investigated with a He plasma jet generated by a two‐ring dielectric barrier discharge (DBD) reactor. The DBD reactor was operated by high‐voltage pulses of alternating polarity (frequency: 20 kHz; pulse width: 4 µs). The electron density of plasma plume was estimated to be 9×10 12 to 10×10 12 cm −3 , and the jet temperature was around 36℃. The plasma jet exhibited the inhibitory effects on the growth of hepatic malignant cells via the generation of reactive oxygen species, which could be potentially applicative in anticancer therapies. The optimization of the operating parameters and configuration of the plasma jet would help increase the possibility in practical cancer treatments.