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Characterization of a non‐thermally operated electrosurgical argon plasma source by electron spin resonance spectroscopy
Author(s) -
Weiss Martin,
Utz Raphael,
Ackermann Michael,
Taran FlorinAndrei,
Krämer Bernhard,
Hahn Markus,
Wallwiener Diethelm,
Brucker Sara,
Haupt Michael,
Barz Jakob,
Oehr Christian
Publication year - 2019
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201800150
Subject(s) - argon , electron paramagnetic resonance , chemistry , aqueous solution , spectroscopy , reactive oxygen species , analytical chemistry (journal) , plasma , radical , oxygen , materials science , nuclear magnetic resonance , chromatography , organic chemistry , biochemistry , physics , quantum mechanics
Non‐thermal plasma treatment is one of the promising options for local anti‐neoplastic treatment of dysplastic lesions and early intraepithelial cancer. Primarily, the antiproliferative properties are driven through the generation of reactive oxygen and nitrogen species. In this study, we investigated the amount and distribution of reactive species generated by a non‐thermally operated electrosurgical argon plasma source using electron spin resonance (ESR) spectroscopy. During the plasma treatment of both, aqueous solution and solid human preputial tissue an increasing amount of different oxygen‐ and carbon‐centered radicals was detected. However, and most probably due to spin trap degradation by the high energy input and the increase of reactive components in aqueous solution, the ESR signal decreased after treatment times exceeding 10 s.