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On the plasma deposition of vancomycin‐containing nano‐capsules for drug‐delivery applications
Author(s) -
Lo Porto Chiara,
Palumbo Fabio,
BuxaderaPalomero Judit,
Canal Cristina,
Jelinek Petr,
Zajickova Lenka,
Favia Pietro
Publication year - 2018
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201700232
Subject(s) - drug delivery , nano , deposition (geology) , plasma , vancomycin , atmospheric pressure plasma , materials science , chemical engineering , nanotechnology , drug , aerosol , chemistry , chromatography , staphylococcus aureus , organic chemistry , sediment , bacteria , pharmacology , composite material , medicine , paleontology , physics , genetics , quantum mechanics , engineering , biology
Aerosol‐assisted atmospheric pressure plasma allows for a one‐step synthesis of vancomycin‐containing nano‐capsules. Morphological and chemical analyses are carried out to estimate how different discharge parameters affect the plasma deposition process. Nano‐capsules size and abundance largely depend on the shell precursor content in the gas feed and on the drug concentration in the aerosol solution. Based on these results a deposition mechanism is proposed, where, interestingly, the key step is the formation of the nano‐capsules in the plasma phase. Furthermore, the related antibacterial activity is proved against Staphylococcus aureus. Preliminary release tests indicate the possible exploitation of the plasma‐deposited vancomycin‐containing nano‐capsules in the drug delivery field, and systems based on other bioactive molecules can be expected.