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Cold physical plasma selects for specific T helper cell subsets with distinct cells surface markers in a caspase‐dependent and NF‐κB‐independent manner
Author(s) -
Bekeschus Sander,
Rödder Katrin,
Schmidt Anke,
Stope Matthias B.,
von Woedtke Thomas,
Miller Vandana,
Fridman Alexander,
Weltmann KlausDieter,
Masur Kai,
Metelmann HansRobert,
Wende Kristian,
Hasse Sybille
Publication year - 2016
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201600080
Subject(s) - immune system , microbiology and biotechnology , population , biology , immunology , effector , t cell , antigen , cell , chemistry , medicine , biochemistry , environmental health
Exposure to cold physical plasma has been proposed to be of therapeutical value in oncology via the generation of a number of biologically relevant redox‐active molecules. Cancer cells can be recognized and eliminated by cells of the immune system, and accordingly many tumors are populated with these cells, among them T helper cells (T H cells). These lymphocyte population is crucial for effector immune responses against tumor antigens, in response to immunogenic cell death in malignant cells. However, a number of T H populations exists, each having distinct phenotypical features. Using a cold atmospheric pressure argon plasma jet, its redox activity was tested in different T H cell subpopulations to better understand the immunological consequences of potential antitumor plasma treatments in vivo.