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Cold Plasma Accelerates the Uptake of Gold Nanoparticles Into Glioblastoma Cells
Author(s) -
Cheng Xiaoqian,
Rajjoub Kenan,
Sherman Jonathan,
Canady Jerome,
Recek Nina,
Yan Dayun,
Bian Ka,
Murad Ferid,
Keidar Michael
Publication year - 2015
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201500093
Subject(s) - colloidal gold , nanoparticle , membrane , penetration (warfare) , biophysics , cell membrane , viability assay , glioblastoma , cell , plasma , materials science , nanotechnology , chemistry , cancer research , biochemistry , biology , physics , operations research , quantum mechanics , engineering
The gold nanoparticles and cold plasma have been widely investigated separately in cancer therapy. In this paper, the two agents were combined in order to achieve a more profound understanding of their interactions in glioblastoma (U87) and normal human astrocytes (E6/E7). Gold nanoparticles were endocytosed at an accelerated rate in the U87 cell membrane due to the plasma treatment. This caused many divots across the cell membrane which made it more porous. On the contrary, in E6/E7 cells, there was no significant difference for penetration of gold nanoparticles or the cell membrane morphology. As proven in previous experiments the addition of the nanoparticles decrease cell viability, allowing the cold plasma to be more efficient. Present work demonstrated the synergistic effect of the two agents, which can be correlated in order to maximize the efficiency.