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Inactivation Effects of Non‐Thermal Atmospheric‐Pressure Helium Plasma Jet on Staphylococcus aureus Biofilms
Author(s) -
Xu Zimu,
Shen Jie,
Zhang Zelong,
Ma Jie,
Ma Ronghua,
Zhao Ying,
Sun Qiang,
Qian Shulou,
Zhang Hao,
Ding Lili,
Cheng Cheng,
Chu Paul K.,
Xia Weidong
Publication year - 2015
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201500006
Subject(s) - biofilm , staphylococcus aureus , microbiology and biotechnology , reactive oxygen species , atmospheric pressure plasma , chemistry , bacteria , intracellular , biophysics , nonthermal plasma , plasma , biology , biochemistry , genetics , physics , quantum mechanics
The antimicrobial effects and mechanism of helium atmospheric‐pressure plasma jet (APPJ) treatment on Staphylococcus aureus biofilms are evaluated in vitro . The S. aureus biofilms are more resistant to the plasma treatment than adherent bacteria. The APPJ‐treated S. aureus biofilms disclose a depth/layer‐related intra‐bacterial ROS accumulation effect. Plasma exposure may induce bacterial oxidative stress and trigger the production of intracellular reactive oxygen species (ROS) in the biofilms, which possibly contributes to bacteria death in addition to direct etching from the exterior of bacteria. The findings provide insights into the mechanism of biofilm inactivation by plasma reactive species and plasma‐induced intracellular ROS.