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Plasma‐Activated Polypropylene Mesh‐Gelatin Scaffold Composite as Potential Implant for Bioactive Hernia Treatment
Author(s) -
Gorgieva Selestina,
Modic Martina,
Dovgan Barbara,
KaisersbergerVincek Maja,
Kokol Vanja
Publication year - 2015
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201400125
Subject(s) - scaffold , gelatin , materials science , composite number , polypropylene , antibacterial activity , implant , composite material , porosity , biomedical engineering , rheology , biodegradation , chemical engineering , chemistry , surgery , bacteria , organic chemistry , medicine , biology , genetics , engineering
Novel, polypropylene mesh (PP mesh ) – gelatin scaffold (GEL scaffold ) composites are prepared from O 2 ‐plasma activated PP mesh , coated with GEL solution being in‐situ structured in a 3D scaffold with by‐preparation tuned, gradual porosity. The fabricated biomimetic‐like composites demonstrate frequency‐dependent rheological behaviour and high (up to 100%) intrinsic and/or by ϵ‐poly‐ L ‐lysine evoked antibacterial activity against S. aureus and E. coli , latter demonstrating preparation‐dependant releasing profile, without triggering in‐vitro cytotoxicity. Finally, long‐term (up to 2 months) biodegradation resistance highlight the composite potential as active, biomimetic barrier in hernia treatment.