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Interactions of a Non‐Thermal Atmospheric Pressure Plasma Effluent with PC‐3 Prostate Cancer Cells
Author(s) -
Gibson Andrew R.,
McCarthy Helen O.,
Ali Ahalm A.,
O'Connell Deborah,
Graham William G.
Publication year - 2014
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201400111
Subject(s) - atmospheric pressure plasma , atmospheric pressure , plasma , nitrite , chemistry , plasma medicine , nonthermal plasma , prostate cancer , nitrate , reactive nitrogen species , reactive oxygen species , materials science , biophysics , analytical chemistry (journal) , environmental chemistry , cancer , medicine , biochemistry , biology , meteorology , physics , organic chemistry , quantum mechanics
The effect of a radio‐frequency driven, microscale non thermal atmospheric pressure plasma jet operated in helium with vol. 0.3% molecular oxygen gas admixture, on PC‐3 prostate cancer cells has been investigated. The viability of cells exposed to the plasma was found to decrease with increasing plasma exposure time, with apoptosis through caspase and PARP cleavage being observed. High concentrations of nitrite and nitrate were detected in growth media exposed to the plasma and were found to increase in a time dependent manner post exposure. This indicates a slow release of reactive nitrogen species into the growth media, which is likely to influence cellular response to plasma exposure.