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Efficacy of Low Temperature Plasma against SCaBER Cancer Cells
Author(s) -
Mohades Soheila,
Barekzi Nazir,
Laroussi Mounir
Publication year - 2014
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201400108
Subject(s) - apoptosis , viability assay , cancer cell , cell culture , plasma medicine , cell , chemistry , microbiology and biotechnology , plasma , biophysics , materials science , cancer , biology , medicine , biochemistry , atmospheric pressure plasma , physics , quantum mechanics , genetics
The efficacy of the plasma pencil is studied for its cancer therapeutics effects against the SCaBER cell line. First, the SCaBER cells in media were treated with different exposure times of low temperature plasma (LTP). Secondly, LTP activated media was generated by treating the media prior to adding it to the cells. Cell viability was assayed at 0, 24, 48, and 72 h after treatments. The results indicate that both treatments alter cell morphology, cell reattachment, and kill SCaBER cells in an exposure time dependent and delayed manner. Caspase‐3 assays reveal that plasma can activate the cells' apoptotic pathways.