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Tailoring Carbon Nanotubes Surface for Gene Delivery Applications
Author(s) -
CifuentesRius Anna,
de Pablo Ana,
RamosPérez Victor,
Borrós Salvador
Publication year - 2014
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201300167
Subject(s) - carbon nanotube , monomer , biocompatibility , materials science , polymer , polymerization , surface modification , nanotechnology , allylamine , methacrylate , covalent bond , gene delivery , plasma polymerization , ionic bonding , chemical engineering , polymer chemistry , chemistry , organic chemistry , genetic enhancement , gene , polyelectrolyte , composite material , biochemistry , engineering , ion , metallurgy
Despite promising advantages, the use of carbon nanotubes (CNTs) for biomedical applications is limited due to their low biocompatibility. This study presents the modification of CNTs by plasma polymerization using two different monomers, pentafluorophenyl methacrylate (PFM) and allylamine (AA). We demonstrated that both type of monomers could be polymerized on the CNT surface in a home‐built plasma reactor, allowing the formation of CNT‐mediated gene delivery vectors. Once polymerized, such polymers provide different properties to the CNT surface enabling the covalent immobilization of the therapeutic gene or its binding through ionic interaction, respectively.