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Plasma Modification of PCL Porous Scaffolds Fabricated by Solvent‐Casting/Particulate‐Leaching for Tissue Engineering
Author(s) -
Intranuovo Francesca,
Gristina Roberto,
Brun Francesco,
Mohammadi Sara,
Ceccone Giacomo,
Sardella Eloisa,
Rossi François,
Tromba Giuliana,
Favia Pietro
Publication year - 2014
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201300149
Subject(s) - polycaprolactone , scaffold , porosity , materials science , biomedical engineering , tissue engineering , chemical engineering , composite material , nanotechnology , polymer , medicine , engineering
The improvement of scaffold performances as cell carriers in a tissue implant is still a challenge in tissue engineering. Since cells in contact with a scaffold firstly sense its top surface before interacting with its macro‐/micro‐porous structure, the insertion of chemical motifs within the body of the scaffold could improve cell colonization through its entire structure. In this study, combinations of plasma deposition and treatment processes have been employed to create chemical gradients inside polycaprolactone porous scaffolds, whose micro‐morphology has been finely characterized with synchrotron radiation computed micro‐tomography. The graded chemical composition of these scaffolds has successfully allowed the increase of cell viability with respect to untreated materials.