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The Mechanism of Plasma Destruction of Enalapril and Related Metabolites in Water
Author(s) -
Magureanu Monica,
Dobrin Daniela,
Mandache Nicolae Bogdan,
Bradu Corina,
Medvedovici Andrei,
Parvulescu Vasile I.
Publication year - 2013
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201200146
Subject(s) - aqueous solution , chemistry , enalaprilat , plasma , degradation (telecommunications) , dielectric barrier discharge , enalapril , molecule , chemical decomposition , mineralization (soil science) , metabolite , decomposition , nonthermal plasma , analytical chemistry (journal) , chemical engineering , electrode , chromatography , organic chemistry , nitrogen , computer science , blood pressure , engineering , angiotensin converting enzyme , telecommunications , biochemistry , quantum mechanics , radiology , medicine , physics
A pulsed dielectric barrier discharge was used for the decomposition of enalapril, its metabolite, enalaprilat, its degradation by‐product, diketopiperazine, as well as their combination, in aqueous solution. The discharge was generated at the interface between gas and the solution which flows as a film on the surface of the inner electrode of the plasma reactor. The degradation mechanism of the studied compounds and the temporal evolution of the reaction intermediates were established from LC–MS analysis. A wide variety of degradation by‐products were formed; at least six new derivatives, not mentioned in literature, were observed. However, most of these by‐products were subsequently degraded to small molecules. The mineralization degree, determined from TOC and COD measurements, was approximately 40%.