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Plasma Sterilization of Pharmaceutical Products: From Basics to Production
Author(s) -
Denis Benjamin,
Steves Simon,
Semmler Egmont,
Bibinov Nikita,
Novak Wenzel,
Awakowicz Peter
Publication year - 2012
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.201100211
Subject(s) - sterilization (economics) , plasma , process engineering , bacillus subtilis , geobacillus stearothermophilus , materials science , chemistry , pulp and paper industry , chemical engineering , engineering , organic chemistry , physics , business , bacteria , biology , finance , exchange rate , foreign exchange market , thermophile , quantum mechanics , genetics , enzyme
For the first time, a commercial low pressure plasma sterilization system integrated in a pharmaceutical filling line is presented. The route from a laboratory plasma reactor to an industry scale plasma sterilization reactor is shown. Absolutely calibrated measurements (e.g. OES and Langmuir probe) yield to a knowledge transfer from an experimental set‐up to an industrial reactor. Spore count reduction of 4 log in 10 s of Geobacillus stearothermophilus and Bacillus subtilis spores prove the applicability of an industrial grade plasma sterilization reactor for transfer isolators typically used in pharmaceutical filling and packaging lines.