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The Irritation Potential of Nonthermal Atmospheric Pressure Plasma in the HET‐CAM
Author(s) -
Bender Claudia,
Matthes Rutger,
Kindel Eckhard,
Kramer Axel,
Lademann Jürgen,
Weltmann KlausDieter,
Eisenbeiß Werner,
Hübner NilsOlaf
Publication year - 2010
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.200900119
Subject(s) - dielectric barrier discharge , atmospheric pressure plasma , irritation , plasma , nonthermal plasma , chemistry , atmospheric pressure , eye irritation , biophysics , medicine , immunology , physics , biology , quantum mechanics , meteorology
To determine a reliable test and validate the use of nonthermal atmospheric pressure plasma on wounds, we selected the Hen's Egg Test–chorioallantoic membrane (HET‐CAM) as an alternative method to the Draize rabbit test to determine the irritation potential of plasma. Irritations of varying intensities provoked by using a dielectric barrier discharge (DBD) and an HF Plasma Jet corresponded to treatment frequencies and exposure times. Pulsed plasma led to the mildest irritations. Depending on the intensity of the irritations, the effects were partially or completely reversible. In the latter case, it may be assumed that this plasma mode can be applied to living tissue without harm. To conclude, the HET‐CAM is suitable for screening plasma sources and parameters for the medical applications of plasma.