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A Cell Therapy for Chronic Wounds Based Upon a Plasma Polymer Delivery Surface
Author(s) -
Haddow David B.,
MacNeil Sheila,
Short Robert D.
Publication year - 2006
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.200600008
Subject(s) - wound healing , medicine , adhesion , polymer , surgery , bandage , biomedical engineering , materials science , chemistry , composite material
Summary: This contribution chronicles the research history over the past ten years behind a cell therapy product for the treatment of chronic wounds. The product is a plasma coated bandage, which delivers autologous cells (keratinoctyes) to non‐healing wound beds. The account given is chronological, starting with the initial investigations of cell (keratinocyte) attachment to a range of plasma polymer surfaces. It details the subsequent selection of acrylic acid plasma polymer surfaces, on which the growth, proliferation and transfer of keratinoctyes to an in vitro wound model are studied. It concludes with the translation of this technology from the laboratory to the clinic, describing the first “proof of concept” study undertaken with non‐healing diabetic foot ulcers.Neuropathic foot ulcer on patient 2 persistent for 2 years.