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Homogeneous and Micro‐Patterned Plasma‐Deposited PEO‐Like Coatings for Biomedical Surfaces
Author(s) -
Sardella Eloisa,
Gristina Roberto,
Senesi Giorgio S.,
d'Agostino Riccardo,
Favia Pietro
Publication year - 2004
Publication title -
plasma processes and polymers
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.644
H-Index - 74
eISSN - 1612-8869
pISSN - 1612-8850
DOI - 10.1002/ppap.200400013
Subject(s) - materials science , adhesion , adhesive , coating , substrate (aquarium) , cell adhesion , polystyrene , chemical engineering , morphology (biology) , oxide , ethylene glycol , composite material , layer (electronics) , polymer , oceanography , metallurgy , geology , engineering , biology , genetics
Summary: Mixtures of diethyl glycol dimethyl ether vapors and argon were used to feed RF (13.56 MHz) glow discharges and coat polystyrene substrates with poly(ethylene oxide) (PEO)‐like thin films. Different power input values have been used to obtain coatings with different cell‐adhesive properties. Cell‐culture experiments showed a tight correlation between the adhesion/morphology of cultured cell‐lines and the chemical composition of the coatings; the ability of PEO‐like coatings to discourage or promote cell adhesion could thus easily be related to the power delivered to the plasma. Combined deposition processes of different PEO‐like coatings have been performed, with the method of physical masking , to produce surfaces micro‐patterned with cell‐adhesive tracks alternating with cell‐repulsive domains. The micro‐arrangement of different cell‐adhesive domains enabled the patterning of cell cultures and induced the alignment of cells along predefined directions.The adhesion pattern of 3T3 murine fibroblasts on a substrate of PEO10W patterned with a PEO5W coating deposited through a G50p mask after 24 h.