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Investigation of anxiety and depressive disorders and psychiatric medication use before and after cancer diagnosis
Author(s) -
Lee MinJing,
Huang ChienWei,
Lee ChuanPin,
Kuo TingYu,
Fang YuHung,
ChinHung Chen Vincent,
Yang YaoHsu
Publication year - 2021
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.5672
Subject(s) - medicine , anxiety , colorectal cancer , depression (economics) , cancer , breast cancer , lung cancer , cohort , liver cancer , population , psychiatry , environmental health , economics , macroeconomics
Abstract Objective Data regarding the prevalence of depression and anxiety among cancer patients, especially before cancer diagnosis, remains scarce. This study investigated the prevalence of these conditions and associated drug use among cancer patients pre‐ and post‐diagnosis. Methods This population‐based cohort study using data from Taiwan's National Health Insurance Research Database recruited patients with a registered cancer diagnosis and matched control between January 1, 2000, and December 31, 2011. We compared the prevalence of anxiety and depressive disorders between cancer patients and non‐cancer participants during a 2‐year period both pre‐ and post‐diagnosis by Pearson's chi‐square test. Psychiatric medication use was also examined for the associated mental condition. Results We examined participants diagnosed with liver ( N = 17,154), colorectal ( N = 30,391), breast ( N = 40,036), gynecological ( N = 23,218), and lung ( N = 15,671) cancer. Before the cancer diagnosis, the prevalence of depression was higher in non‐cancer participants than in gynecological cancer patients ( p = 0.018) but anxiety is higher in liver, colorectal, and lung cancer patients when compared to non‐cancer participants ( p < 0.05). After the cancer diagnosis, the prevalence of anxiety and depression became significantly higher in all enrolled cancer patients than non‐cancer participants ( p < 0.05). Similar results were observed in psychiatric medication use trends. Conclusions This study proposed that patients with liver, colorectal, and lung cancer had an increased risk of developing anxiety, which might be a sentinel diagnosis. The participants had a significantly higher level of anxiety and depressive disorder post‐diagnosis, which highlights the importance of the care for both mental and physical conditions in cancer management.