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The impact of long‐term androgen deprivation therapy on cognitive function and socioeconomic decision making in prostate cancer patients
Author(s) -
Holtfrerich Sarah Katharina Charlotte,
Knipper Sophie,
Purwins Janna,
Castens Jasmin,
Beyer Burkhard,
Schlomm Thorsten,
Diekhof Esther Kristina
Publication year - 2020
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.5442
Subject(s) - androgen deprivation therapy , prostate cancer , socioeconomic status , medicine , testosterone (patch) , cognition , androgen , oncology , effects of sleep deprivation on cognitive performance , quality of life (healthcare) , psychology , clinical psychology , cancer , psychiatry , hormone , population , nursing , environmental health
Objective Androgen deprivation therapy (ADT) enhances survival of advanced prostate cancer patients and is therefore used as a concomitant therapy. However, ADT has been reported to cause negative side effects on cognition and emotional processing. So far, research referred to the effects of short‐term treatment. Since the brain may adapt to androgen deprivation, we were especially interested in the long‐term effects of ADT on cognitive and socioeconomic decision making. Methods Participants underwent a battery of tests that have been associated with testosterone. We compared the results of three matched test groups: (1) prostate cancer patients with ADT up to 20 years, (2) prostate cancer controls without treatment and (3) healthy controls. We further measured the morning testosterone content in participants' saliva. Results Testosterone concentration was positively associated with visuospatial performance across and within the test groups. Patients with long‐term ADT showed an overall decline in cognitive performance. Compared with untreated patients, ADT was also associated with a reduced intergroup bias during socioeconomic decision making, which was in line with previous observations in young men suggesting that testosterone may promote ingroup favoritism. Finally, depression scores were increased in ADT, while quality of life was negatively associated with the treatment. Conclusion These findings conform to results made after short‐term treatment. ADT promotes negative side effects on cognitive function. We also show for the first time that testosterone deprivation may affect socioeconomic decision making. Nevertheless, it should be emphasized that these effects cannot outweigh the previously described advantages of ADT in the treatment of prostate cancer.