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Relationship between cognitive functioning, mood, and other patient factors on quality of life in metastatic brain cancer
Author(s) -
Marotta Dario,
Tucker Zachary,
Hayward Emily N.,
Gerstenecker Adam,
Gammon Meredith,
Mason Matthew,
Willhelm Gabrielle,
Bae Helen,
Triebel Kristen
Publication year - 2020
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.5401
Subject(s) - neurocognitive , mood , quality of life (healthcare) , clinical psychology , cognition , psychology , social support , verbal memory , cognitive skill , medicine , psychiatry , psychotherapist
Objective Neurocognitive functioning (NCF), mood disturbances, physical functioning, and social support all share a relationship with health‐related quality of life (HRQOL). However, investigations into these relationships have not been conducted in persons with brain metastases (BM).Patients and methods Ninety‐three newly diagnosed persons with BM were administered various cognitive batteries. Data were collected across a wide range of categories (ie, cognitive, demographic, disease/treatment, mood, social support, physical functioning). The Functional Assessment of Cancer Treatment (FACT) scale was used to measure HRQOL. Results Mood and physical function correlated with lower HRQOL in every measured domain. Verbal learning and memory correlated with every FACT subscale except emotional quality of life. Social support also correlated with several HRQOL domains. Stepwise linear regression revealed that mood predicted general well‐being and several FACT subscales, including physical, emotional and cognitive well‐being. Social support and physical health were predictive of general well‐being. Verbal learning and memory predicted cognitive well‐being. Conclusion HRQOL is a complex construct affected by numerous variables. In particular, mood, physical functioning, and learning and memory were important predictors of HRQOL, and clinicians are encouraged to obtain information in these areas during baseline assessments in persons with BM.