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Use of antidepressants in women after prophylactic bilateral oophorectomy: A Danish national cohort study
Author(s) -
Abildgaard Julie,
Ahlström Magnus Glindvad,
Nielsen Dorte Lisbeth,
Daugaard Gedske,
Lindegaard Birgitte,
Obel Niels,
Lidegaard Øjvind
Publication year - 2020
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.5290
Subject(s) - medicine , oophorectomy , hormone replacement therapy (female to male) , depression (economics) , cohort , danish , family history , cohort study , gynecology , population , hysterectomy , obstetrics , surgery , testosterone (patch) , linguistics , philosophy , macroeconomics , environmental health , economics
Abstract Objective To investigate the association between prophylactic bilateral oophorectomy and use of antidepressants in women with a family history of cancer. Methods Nationwide population‐based cohort study using Danish National Registries including women oophorectomized due to a family history of cancer (n = 2,002) and an age matched reference group (n = 18,018). Analyses were stratified by age at time of bilateral oophorectomy and use of hormone replacement therapy (HRT). Results Women oophorectomized at age ≤ 45 years were more likely to use antidepressants from the first year after bilateral oophorectomy (OR = 1.34; 95 % CI: 1.08‐1.65) compared to the reference group. Women oophorectomized at age 46‐55 years and at age >55 years had no significantly increased use of antidepressants (OR = 0.90; 95 % CI: 0.68‐1.18 and OR = 1.14; 95 % CI: 0.81‐1.61). The increased use of antidepressants in women oophorectomized at age ≤ 45 years was limited to women treated with HRT (OR = 1.51; 95 % CI: 1.18‐1.94) whereas women oophorectomized at age ≤ 45 years not treated with HRT had no increased use of antidepressants (OR = 1.03; 95 % CI: 0.70‐1.51). Conclusions Women oophorectomized due to a family history of cancer at age ≤ 45 years were more likely to use antidepressants after bilateral oophorectomy. The increased use of antidepressants was limited to women treated with HRT. The study calls for further large‐scale studies to understand how bilateral oophorectomy and concomitant HRT affects risk of depression in women with a family history of cancer.