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Acceptance and commitment therapy for adults with advanced cancer (CanACT): A feasibility randomised controlled trial
Author(s) -
Serfaty Marc,
Armstrong Megan,
Vickerstaff Victoria,
Davis Sarah,
Gola Anna,
McNamee Philip,
Omar Rumana Z.,
King Michael,
Tookman Adrian,
Jones Louise,
Low Joseph T.S.
Publication year - 2019
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.4960
Subject(s) - medicine , randomized controlled trial , physical therapy , cancer , acceptance and commitment therapy , population , normative , clinical trial , test (biology) , clinical endpoint , intention to treat analysis , family medicine , intervention (counseling) , nursing , paleontology , philosophy , environmental health , epistemology , biology
Objective To understand the feasibility of recruiting people with advanced cancer into a randomised controlled trial of acceptance and commitment therapy (ACT) vs a standardised talking control (TC) and delivering ACT to this population; to explore the acceptability of outcome measures and generate normative data. Methods This was a feasibility two‐arm randomised controlled trial. Participants were attendees with advanced cancer at one of three hospice‐based day‐therapy units in London, United Kingdom, who demonstrated low scores on the Functional Assessment of Cancer Therapies—General (FACT‐G). The primary end point was 3 months. Results The recruitment target was 54 participants; 42 people were recruited and randomised to up to eight individual sessions of ACT (n = 20) or TC (n = 22). Eighteen out of 42 (43%) of participants completed the primary outcome at 3 months, and at least one follow‐up was available in 30/42 (71%) participants. An exploratory analysis revealed a non‐significant adjusted mean difference after 3 months in the main outcome FACT‐G of −3.41 (CI = −18.61‐11.79) with TC having better functioning. Over 6 months, the adjusted mean difference between trial arms was 2.25 (CI = −6.03‐10.52) in favour of ACT. Conclusions It is feasible to recruit people with advanced cancer in a trial of ACT versus TC. Future research should test the effectiveness of ACT in a fully powered trial.

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