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Psychological factors at early stage of treatment as predictors of receiving chemotherapy at the end of life
Author(s) -
Fujisawa Daisuke,
Temel Jennifer S.,
Traeger Lara,
Greer Joseph A.,
Lennes Inga T.,
Mimura Masaru,
Pirl William F.
Publication year - 2015
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.3840
Subject(s) - medicine , chemotherapy , quality of life (healthcare) , anxiety , regimen , depression (economics) , chemotherapy regimen , lung cancer , stage (stratigraphy) , end of life care , cancer , clinical trial , palliative care , oncology , psychiatry , nursing , economics , macroeconomics , paleontology , biology
Administration of chemotherapy in the last 14 days of life is a widely recognized indicator of poor end‐of‐life (EOL) care. The current study aimed to investigate predictors of this outcome, focusing on patients' self‐reported psychological symptoms. Methods and Materials This is a secondary analysis of a randomized controlled trial that examined the efficacy of early palliative care integrated with standard oncology practice in patients with metastatic non‐small cell lung cancer (NSCLC). We analyzed associations between receipt of chemotherapy within 14 days of death and demographic, clinical, and quality‐of‐life variables in the 125 patients who received chemotherapy in the course of their illness and died during the 50‐month follow‐up. Results Twenty‐five patients (20%) received chemotherapy within the last 14 days of their life. Among demographic and clinical variables, only route of chemotherapy was significantly associated with receipt of chemotherapy within 14 days of death (oral 34.1% vs. intravenous (IV) 12.3%, p < 0.05). In the subsample of participants who received IV chemotherapy as their last regimen, greater anxiety and depression and lower quality of life in emotional, social, and existential domains were associated with greater likelihood of receiving chemotherapy at the EOL. These associations were not observed in patients who received oral chemotherapy as their last regimen. Conclusion Anxiety, depression, and worse psychological quality of life at early stage of treatment may be associated with the receipt of IV chemotherapy at the EOL. Further research is needed to examine how these factors might influence decision‐making about the discontinuation of chemotherapy at the EOL. Copyright © 2015 John Wiley & Sons, Ltd.