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Ifosfamide neuropsychiatric toxicity in patients with cancer
Author(s) -
AliciEvcimen Yesne,
Breitbart William S.
Publication year - 2007
Publication title -
psycho‐oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.41
H-Index - 137
eISSN - 1099-1611
pISSN - 1057-9249
DOI - 10.1002/pon.1161
Subject(s) - ifosfamide , medicine , vomiting , nausea , delirium , chemotherapy , toxicity , complication , oncology , psychiatry , cisplatin
Ifosfamide is a chemotherapy agent commonly used in the treatment of several solid tumors and hematologic malignancies. Common ifosfamide toxicities are bone marrow suppression, alopecia, nausea and vomiting. Less common, but striking, are the rare but dramatic neuropsychiatric toxicities with discrete neurological symptoms and delirium. We report here a case of ifosfamide neuropsychiatric toxicity which presented with an isolated psychotic disorder with delusions, and was successfully treated with methylene blue. Current literature on treatment and prophylaxis of this clinically challenging chemotherapy‐induced complication is presented. Copyright © 2007 John Wiley & Sons, Ltd.