Open AccessTunable degradation of polyethylene glycol‐like polymers based on imine and oxime bonds
Author(s) -
Collins Joe,
Xiao Zeyun,
Connal Luke A.
Publication year - 2017
Publication title -
journal of polymer science part a: polymer chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.768
H-Index - 152
eISSN - 1099-0518
pISSN - 0887-624X
DOI - 10.1002/pola.28856
Subject(s) - oxime , imine , hydroxylamine , polymer , polyethylene glycol , degradation (telecommunications) , chemistry , polymer chemistry , peg ratio , organic chemistry , catalysis , computer science , economics , telecommunications , finance
Hydrolytically degradable PEG‐like polymers were prepared using oxime and/or imine chemistry. Polymers based on oxime linkages show higher stability than imine‐based polymers. By blending the oxime and imine bonds, polymers with tuneable, two‐stage degradation profiles could be prepared. Finally, end functional bioconjugates are prepared using unreacted hydroxylamine end groups.