Open AccessPreparation, properties, and antibacterial behavior of a novel cellulose derivative containing lactam groups
Author(s) -
Joubert Fanny,
Sharples Gary J.,
Musa Osama M.,
Hodgson David R. W.,
Cameron Neil R.
Publication year - 2014
Publication title -
journal of polymer science part a: polymer chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.768
H-Index - 152
eISSN - 1099-0518
pISSN - 0887-624X
DOI - 10.1002/pola.27441
Subject(s) - surface modification , chemistry , hydroxymethyl , polymer chemistry , hydroxyethyl cellulose , cellulose , thermal stability , polymer , chemical modification , organic chemistry , chemical engineering , engineering
Lactam groups were introduced onto the backbone of hydroxyethyl cellulose (HEC) to modify properties, such as solubility in organic solvents and solution viscosity and to introduce possible antibacterial activity. Functionalization was achieved using 1‐(hydroxymethyl)‐2‐pyrrolidinone (HMP), and the functionalization reactions were investigated using NMR spectroscopy. The covalent attachment between HEC and HMP was confirmed using 1 H‐ 13 C correlated NMR experiments. Degrees of functionalization were calculated using integrated 13 C NMR spectra, with values of up to 0.9 being demonstrated on the primary alcohol functionality of HEC. The functionalized HECs showed markedly different properties to unfunctionalized HEC, including the ability to swell considerably in water. Functionalized HEC displayed increased thermal stability and reduced solution viscosity compared with unfunctionalized HEC. Moreover, functionalization altered the bacterial adhesion characteristics compared with unfunctionalized HEC. © 2014 The Authors. Journal of Polymer Science Part A: Polymer Chemistry Published by Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015 , 53 , 68–78